Acute myocardial infraction (AMI) commonly known as heart may remain undetected and be severely catastrophic causing immediate death or other permanent injuries. The risk of death AMI is very high within the first hours of chest pain onset and traditional methods to test the serological blood to detect the myocardial damage is overwhelmingly long. Cardiac troponin is the key biomarker which is detectable only in response to cardiac damage making it a preferred choice for AMI diagnosis.
We have proposed to develop a microneedle integrated biosensor to identify troponin in interstitial fluid (ISF). Primarily, the biosensor will be composed of three main components: 1) microneedle array for minimally invasive skin penetration; 2) integration of the microneedle array with the electronic components for ISF extraction; and 3) sensing and identification of troponin. Furthermore, this study will analyse different materials and geometrical shape of the microneedles, design aspects of the electronic components ( transducer, signal analysis, etc) to improve ISF sampling time and volume.
This ISF extraction strategy which combined with microneedles and biosensor paves the way to develop a platform not only to detect troponin but also minimizing the detection time without the need of painful finger-stick blood sampling.
For more information, please contact the Graduate Research School.